What is Leaky Gut Syndrome?
Leaky gut syndrome is one of the major factors in nearly every inflammation condition. Most people have this condition but no very little about it. This article will help to uncover the question, “what is leaky gut syndrome?”
The digestive tract is loaded with trillions of microorganisms that form a natural ecosystem commonly called the gut flora. This ecosystem is designed to be symbiotic in that it benefits both the individual and the microbes. Certain lifestyle stressors throw off the natural symbiosis and cause a rise in pathogenic microbes, chronic gut inflammation and damage to the gut lining. When this happens it can cause a condition known as intestinal permeability or leaky gut syndrome.
The digestive tract is a dark, moist environment that provides a steady stream of fluid and nutrition and is therefore an optimal breeding ground for microbes of all different types. There are approximately 500 different species of microorganisms within the gut (1).
This makes up anywhere from three to six pounds of weight within the individual. The vast majority of these are beneficial and help metabolize food particles and form highly absorbable nutrients for the person to digest.
Progenic vs Pathogenic Organisms:
This internal ecosystem is dependent upon certain beneficial species being widespread and in control. These good bacteria are progenic in that they support life. These bacteria provide a protective barrier that guards the intestinal wall against pathogenic bacteria, parasites, fungi, viruses & environmental toxins. These organisms also create anti-microbial substances that destroy pathogenic organisms. They are very powerful natural antibiotics, anti-virals, & anti-fungals (2, 3).
Humans would be unable to survive without a rich array of good bacteria. The critical species are the Lactobacteria that predominate the small intestine and the Bifidobacteria that predominate the large intestine. Humans depend on these organisms to absorb nutrients and fight against infection. These probiotic species which are found in Omnibiotic Life are important for protecting against the formation of leaky gut syndrome.
These organisms also support the mucous membranes of the reproductive tract, respiratory system and sinus cavities. These organisms produce what is estimated to be about 83% of the bodies immune system (4).
Bacterial Balance is Passed Down:
We initially inherit and acquire our gut flora from our mother. The most important meal a newborn has is the exposure and inoculation of microbes as the baby travels through the mucous membrane of the vaginal canal (5). These microbes travel into the warm and moist areas of the baby and begin to form large, healthy colonies that support the formation of natural immunity. Gut flora continues to transfer over to the baby through breast milk (5).
The microbial foundation of the baby is determined by the microbial balance of the mother. Mothers with poor bacterial balance give their children an inherently poor survival ability from the start. These are typically the children that are constantly sick, have food & environmental allergens as well as neurodevelopmental & sensory processing disorders (6).
Bottle fed children are at the highest risk for poor gut function due to the toxic ingredients in typical bottle based formulas. Breast feeding, whole-food based diet and natural toxin free lifestyle offer a significant defense against leaky gut syndrome (7).
Leaky Gut Syndrome:
When the gut flora is damaged from environmental toxins such as anti-biotic usage, chlorinated water, industrial meat, processed food & drinks, etc. it allows for the pathogenic species to take control. This would include Staphylococci, Streptococci, Bacilli, Clostrida, Candida Albicans, Enterobacteria & other parasites.
These pathogenic species eat through the intestinal wall and cause gaps in the gut lining. This is called intestinal permeability or leaky gut syndrome. These gaps allow for large food particles, yeast, bacteria and environmental toxins to cross into the bloodstream. These things travel through the blood stream and lodge into joints, neural tissue such as the brain, the liver and other major organs.
The immune system reacts by creating an inflammatory response in these areas. Due to the damaged gut lining allowing an opening for the toxins continue to pour into the bloodstream and lodge in the body it leads to the inflammatory conditions becoming chronic (8). This destroys brain, organ and joint tissue and rapidly ages the body.
Toxins and Leaky Gut Syndrome:
The gut flora has two major arms. The first arm senses our environment by reading the environmental toxins that are coming into the body. When these environmental factors such as dust, chemicals, animal hair & pollen fall on the mucous membranes the progenic bacteria sense and react to them.
The second arm is responsible for immune activation and inflammatory based reactions. When the first arm is damaged the second arm begins to become hyperactive which leads to autoimmune reactions. Depending upon the genetic tendencies of the individual this can result in asthma, allergies, rheumatoid arthritis, multiple sclerosis, Hashimoto’s or Graves thyroiditis, fibromyalgia, Crohn’s disease, etc.
The Function of Beneficial Microflora:
The beneficial microflora digest our food and produce enzymes that metabolize protein into absorbable amino acids. These key enzymes also transport key vitamins, minerals and other nutrients through the intestinal wall and into the blood stream where they are effectively carried to cells that are in need of these nutrient packages.
These beneficial species also help the body produce and metabolize vitamin K2, B1, B2, B3, B6, B12, folate & pantothenic acid. Without adequate microflora production the body will suffer from poor calcium metabolism, neuromuscular function and chronic inflammatory conditions due to deficiencies in these very important nutrients.
Once the gut membrane is damaged, we need to help support the healing of the leaky gut syndrome. This is a 4 step process of:
1) Remove Toxins, Inflammatory Foods and Bad Microbes
2) Repair the Gut Membrane
3) Replenish the Mucosal Membrane
4) Reinnoculate with Health Microbes.
Many individuals fail to ever effectively repair their gut membrane and replenish the gut membrane. My go to supplement for the repair & replenish process is Gut Repair which is loaded with natural compounds such as L-glutamine, Aloe Vera, Arbinogalactin, DGL, etc. These nutrients and herbs help to heal and seal the gut membrane and replenish the mucosal membrane. This has been a core product for individuals who are trying to improve their gut function, reverse autoimmunity, reduce pain, etc.
Avoid Antibiotics and Use Probiotics:
Antibiotics are the most lethal thing for our microbial balance (9). After a round of anti-biotics it will take at least four to eight weeks to reestablish the gut (10). This time period is an opportunistic window for parasites to establish themselves on the gut wall. Eating conventional meat, dairy and poultry products can be as dangerous as taking anti-biotic prescriptions due to the amount of anti-biotics present in these products.
A diet high in fermented foods and essential fats and low in sugar and other toxic food sources will speed this process up. Probiotic supplements are especially important to speed the re-inoculation time as well.
Medications of all types including contraception pills and corticosteroids are extremely hazardous to the gut flora (11). Dental fluoride treatments and fluoride based toothpaste are damaging to the microbial balance. Chlorinated water is particularly dangerous as it sterilizes our gut and repeated exposure destroys the progenic bacteria in the gut.
The best probiotic I have found for challenging digestive health cases is SBO Probiotics – Ultimate. This is a combination of hypoallergenic, soil based organisms that are rich in fumic an humic acids. I have my clients use this and rotate it with Probiocharge to get a diverse array of microbial species.
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Sources For This Article Include:
1. Science Direct: Gut Flora in Health and Disease Link Here
2. Science Direct: Potential of Selected Lactic Acid Bacteria to Produce Food Compatible Antifungal Metabolites Link Here
3. Science Direct: A Novel Eukaryotic Cell Culture Model to Study Antiviral Activity of Potential Probiotic Bacteria Link Here
4. Furness JB, Kunze WA, Clerc N. Nutrient tasting and signaling mechanisms in the gut. II. The intestine as a sensory organ: neural, endocrine, and immune responses. Am J Physiol. 1999 Nov;277(5 Pt 1):G922-8. PMID: 10564096
5. Mead MN. Contaminants in Human Milk: Weighing the Risks against the Benefits of Breastfeeding. Environmental Health Perspectives. 2008;116(10):A426-A434. Link Here
6. Mercola: How Your Gut Flora Influences Your Health Link Here
7. Mercola: Four Dangers to Infants You Need to Be Aware of Link Here
8. Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec;29(6):902-10. PMID: 19112401
9. Grönlund MM, Lehtonen OP, Eerola E, Kero P. Fecal microflora in healthy infants born by different methods of delivery: permanent changes in intestinal flora after cesarean delivery. J Pediatr Gastroenterol Nutr. 1999 Jan;28(1):19-25. PMID: 9890463
10. Fouhy, C.M. Guinane, S. Hussey, R. Wall, C.A. Ryan, E.M. Dempsey, B. Murphy, R.P. Ross, G.F. Fitzgerald, C. Stanton, and P.D. Cotter, 2012. High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin. Antim. Agents Chemother. 56:5811-5820.
11. Hassan T. Pharmacologic considerations for patients taking oral contraceptives. Conn Dent Stud J. 1987 Mar;7:7-8. PMID: 3155374
What about Splenda, heard it destroys gut flora?
Yes, Mary – Splenda destroys the gut as well as it is basically a number of chlorine molecules.
1.Does everyone with food allergies have a leaky gut?
2.is it recommended to do a lab test (lactulose and mannitol test)to make sure of it?
3.what tests can be done for discocering parasites in intestine,candida or the like?
4.My daughter(2.5 yrs) has many food allergies, hives,is hypothyroid and has
been chronically constipated since birth. It is very hard to keep a child on meat and broth for a minimum of 3 days, what would be an alternative option to heal the gut?
5.is it recommended to give supplements to aid healing process like probiotics,digestive enzymes, DG licorice, glutamine, Zn,Mg, Se, vit c, for young kids?
6.mang kids outgrow food allergies, without diet change, how does that happen?
7.when a child has hypothyroid,chronic constipation and food allergies,what should be tackled first?and wouldn’t the broth only diet be constipating for an already constipated child?
Thank you
Candida Albicans is a fungus, better known as yeast. It is not a bacteria. Treatment of such would be different than for a bacteria.
Yes absolutely!
Dr. Jockers, I am trying to make an informed decision to get or not to get a second kidney transplant. I believe in the healing power of the body. I know that no one can guarantee that I could regenerate my kidney to function without dialysis. But if I give my body everything it needed to do so, do you believe that it is possible. I do have a little residual function. Thank you,
Sonja
Allergic to egg whites ,wheat, shellfish, bees, sesame seeds. Developed histamine intolerance 2 years ago. Trying to stay off of Zyrtec and solve the problem by taking DAO and allergen-free probiotics. It works for 4 days. What should I do to stay away from the head to toe ichy rash. I’m almost a vegetarian.
Sorry to hear that! Here is a helpful article https://drjockers.com/suffering-histamine-intolerance/
The Gut Repair formula contains L-Glutamine and I think I should avoid that due to low-GABA type of symptoms. What do you recommend to do in terms of a product to take for gut healing if I cannot take the Gut Repair?
Hello Ernst, most people with low-GABA symptoms actually do very well with glutamine. The key is to make sure you are taking magnesium and a good vitamin B6 with it and it can be a game changer because it helps restore the intestinal lining and reduces inflammation.
Hi Dr. J.,
I am undergoing chemotherapy for multiple myeloma. My doctor insists I take an antibiotic and I have for over 3 years, although I’ve cut the dosage in half twice since then without telling him. Can I safely stop the antibiotic entirely with my immune system being compromised? If not, what hope do I have of healing my gut? My doctor expects me to live another 7 years minimum by following his protocol. Please advise.
Thank you.