Uric Acid: A Key Player in Cardio, Brain, and Metabolic Diseases

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uric acidUric Acid: A Key Player in Cardio, Brain, and Metabolic Diseases

Uric acid is a natural waste product in your blood that helps to break down purines. Once uric acid dissolves in your blood, it moves through your kidneys that leaves your body through urine. However, if your body cannot remove all excess uric acid, it can lead to a build-up causing high uric acid levels called hyperuricemia. High uric acid levels may lead to kidney stones, gout, and other health issues. The good news is that it’s possible to reduce your uric acid levels with the help of some natural support strategies.

In this article, you will learn what uric acid is. You will learn about the connection between fructose and hyperuricemia. You will learn about the connection between purines and uric acid. I will discuss the top health conditions associated with high uric acid. I will explain how testing works for uric acid levels.

I will go over the benefits of a Comprehensive Blood Analysis. You will learn about how genetic polymorphism may be associated with high uric acid. Finally, I will offer some natural support strategies to reduce high uric acid levels.

uric acid

What Is Uric Acid

Uric acid is a natural waste product in your blood. It is a chemical made by your body to break down purines. Purines are chemicals created in your body. They are also found in certain foods and drinks. 

In a healthy body, most uric acid will dissolve in your blood, move through your kidneys, and get removed through the urine. Food high in uric acid and certain health issues, including diabetes, high blood pressure, and fatty liver disease, however, may lead to too much uric acid staying in your body.

Hyperuricemia is a condition that refers to too much uric acid remaining in the body. It may lead to crystals formation, causing gout when settling in your joints or kidney stones when settling in your kidneys. If left untreated, high uric acid levels may cause kidney damage, bone and joint issues, tissue damage, or heart disease.  

uric acid

Fructose and Uric Acid

Fructose is a monosaccharide, which is a type of sugar. Because fructose mainly occurs in fruits, it is often referred to as fruit sugar. Honey, sugar cane, sugar beet, and many vegetables also contain fructose.

When your body breaks down fructose, it releases purines. To break down purines, your body releases uric acid. If you consume too much fructose, it will lead to increased purine and then uric acid release. Your body may not be able to keep up, which may cause high uric acid levels. Research suggests that there may be a connection between fructose and uric acid.

A 2011 review published in Seminars in Nephrology has found that there are increased issues with hyperuricemia associated with the consumption of fructose and sweetened drinks (1). A 2017 review published in Nutrients has also found that high fructose intake may increase uric acid levels and associated risk of cardiometabolic disorders (2). A 2020 review published in Biomedicine & Pharmacotherapy has also found that increased fructose may increase the risk of hyperuricemia (3)

uric acid

Purines and Uric Acid

Your body produces uric acid to break down purines. Purines are created when breaking down fructose. They are also found in many foods and drinks. Foods higher in uric acid include salmon, shrimp, sardines, lobsters, mackerel, anchovies and some other seafood, red meat, liver and other organ meats, dried beans, peas, alcohol, and food and drinks made with high fructose corn syrup.

If you eat too many foods high in purines, it may lead to increased uric acid production and uric acid build-up. Thus eating too many foods high in purines may lead to health issues. A 2012 study published in Annals of the Rheumatic Diseases has found that eating foods high in purine may lead to recurrent gout attacks (4).

A 2012 cross-sectional study published in PLoS One has found that vegetables high in purine may increase uric acid levels (5). Reducing the intake of purine-rich vegetables, however, may help to lower uric acid levels.

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Top Conditions Associated with High Uric Acid

Untreated high uric acid can lead to serious health consequences. Here is a list of the top health conditions associated with high uric acid levels.

Gout

Gout is a type of inflammatory arthritis characterized by pain, tenderness, swelling, and redness that comes in sudden and severe attacks (6). It can affect one or more joints and usually occurs in the big toe. Gout is generally caused by hyperuricemia or high uric acid levels that can build up in your joints. 

A 2016 study published in Postgraduate Medicine has found that targeting serum uric acid is important for the treatment of gout (7). According to a 2017 review published in the Journal of Advanced Research, diet and lifestyle changes may be an important part of targeting uric acid levels in gout (8). It’s important to note that though gout is caused by high uric acid levels, hyperuricemia doesn’t always result in gout (6).

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Diabetes

In type 2 diabetes, your body is unable to regulate and use glucose (sugar) as fuel as it should. Over time this will lead to too much glucose circulating in your bloodstream causing high blood sugar levels and blood sugar fluctuations. Long-term, this may lead to the immune, nervous system, and circulatory health issues.

High uric acid may increase the risk of insulin resistance which may increase the risk of prediabetes and type 2 diabetes. Women are at higher risk than men. A 2016 cohort study published in the Annals of Rheumatic Disease, has found that women with gout are 71 percent at a higher risk of developing type 2 diabetes, while men only have a 22 percent increased risk (9)

However, it’s not only high uric acid and gout that increase the risk of type 2 diabetes, but type 2 diabetes may also increase the risk of high uric acid and gout. People with type 2 diabetes are often overweight or obese and carry extra fat around their belly area.

This may interfere with healthy kidney function, which may also reduce your body’s ability to remove uric acid as fast and as effectively as it should. According to a 2020 population-based cohort study published in the Annals of Internal Medicine, type 2 diabetes patients who were prescribed sodium-glucose transport protein 2 (SGLT2)  inhibitors, a diabetes medication, had a lower risk of developing high uric acid and gout than those who were not (10).

balance blood sugar

Fatty Liver Disease

Fatty liver disease means that there is too much fat stored in your liver cells. Nonalcoholic fatty liver disease (NAFLD) refers to a group of liver conditions that are characterized by a fatty liver and affects people who only drink little to no alcohol. Fatty liver disease can cause liver inflammation, cirrhosis (advanced scarring of the liver), and liver failure.

Fatty liver disease is often associated with high uric acid levels. According to a 2019 study published in Medicina (Kaunas), high uric acid levels are linked to non-alcoholic fatty liver disease (11).

The study has found that hyperuricemia in non-alcoholic fatty liver disease are a common issue and they are more common in non-obese and younger patients with non-alcoholic fatty liver disease. A 2017 study published in Lipids in Health and Disease has found that high uric acid levels are a problem in non-obese adults with non-alcoholic fatty liver disease (12).

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Hypertension

Hypertension or high blood pressure means that the long-term force of the blood against your artery walls is too high. High blood pressure is 140/90 or higher. Hypertension may increase the risk of heart disease, stroke, and mortality. High blood pressure is also associated with high uric acid.

According to a 2019 study published in Medicina (Kaunas), high uric acid levels are linked to hypertension (11). A 2010 review published in the Current Rheumatology Report has found that hyperuricemia may increase the risk of hypertension (12).

A 2003 review published in Hypertension has found that the connection between high uric acid levels and hypertension may lie in reduced renal blood flow (14). Researchers found that reducing uric acid levels may reduce the risk of hypertension. A 2020 review published in Hypertension Research has explained that hyperuricemia may cause endothelial damage and dysfunction which may lead to hypertension (15).

Cognitive Decline

Cognitive decline can range anywhere from mild forgetfulness and other signs of mild cognitive impairment to dementia. Dementia is a more severe cognitive decline that can seriously impact one’s life.

One form of dementia is Alzheimer’s disease. Signs of cognitive decline may include forgetting dates, appointments, events, or recent conversations, losing a sense of direction, having trouble organizing tasks, having difficulties following directions or instructions, and feeling overwhelmed by plans or decisions.

Cognitive decline may also be linked to high uric acid levels. A 2018 review published in Nutrients has found that uric acid levels may play a role in modulating cognitive function and hyperuricemia may play a role in the increased progression of dementia, Alzheimer’s disease, and Parkinson’s disease (16). A 2020 study published in Frontiers in Aging Neuroscience has found that hyperuricemia are linked to cerebral hypometabolism in Alzheimer’s disease (17).

Kidney Disease

Your kidneys are a pair of organs shaped like beans that filter your blood to remove any waste and extra water. If you have kidney disease, it means that your kidneys are damaged and unable to filter your blood effectively. Kidney disease may lead to kidney failure requiring dialysis or a kidney transplant. 

As your kidneys filter your blood, excess uric acid may build up. This build-up can cause the formation of urate crystals which may scar and damage your kidneys. Ongoing kidney damage from uric acid buildup can lead to kidney disease.

A 2011 review published in Seminars in Nephrology has found a link between high uric acid levels and chronic kidney disease (18). A 2015 review published in Disease Markers has found that uric acid may be a potential marker for kidney disease and renal failure (19)

kidneys, Healthy Kidneys: Best Foods and Natural Remedies

Osteoarthritis 

Osteoarthritis is a type of arthritis. It is the most common form worldwide and your risk increases with age. Osteoarthritis most commonly affects your knees, hips, hands, or spine, but it can affect just about any joint in your body. Osteoarthritis may also be linked to high uric acid levels.

A 2011 study published by Duke University Medical Center has found that high uric acid levels can increase the risk of osteoarthritis (20). They found that high uric acid levels may increase the risk even in those without gout. A 2017 review published in Frontiers in Medicine (Lausanne) has found that gout and high uric acid levels may increase the risk of osteoarthritis (21).

osteoarthritis, Osteoarthritis: Symptoms, Causes & Natural Support Strategies

Osteoporosis 

Osteoporosis is a condition that weakens and thins your bones. As a result, they become more fragile and can fracture or break more easily. Osteoporosis most often affects the hips, wrist, and spine. The risk of osteoporosis may increase with age and is more likely to affect post-menopausal women.

Osteoporosis is often connected to high uric acid levels. A 2018 review published in Acta Pharmacologica Sinica has found that high uric acid levels are associated with osteoporosis and related fractures in post-menopausal females (23). A 2019 review published in Nutrients has found that high uric acid may inhibit vitamin D production, increase inflammatory cytokines and free radicals, and may reduce bone density and increase the risk of osteoporosis and bone fractures (24).

Osteoporosis, Osteoporosis: Symptoms, Causes and Natural Support Strategies

PCOS

Polycystic ovarian syndrome (PCOS) is a hormonal disorder that affects women of reproductive age. It may be characterized by excess androgen levels, prolonger periods or infrequent periods as the ovaries may fail to release eggs regularly or release more eggs than normal.

Symptoms beyond prolonged or missed periods may include cysts on the ovaries, weight gain, oily skin, acne, excess body hair, dark skin patches around the armpit, neck, or under the breast, and infertility. High uric acid in women is one of the risk factors for developing PCOS.

A 2018 study published in Reproductive Biology and Endocrinology has found that at 25.48 percent of women with PCOS had hyperuricemia compared to only 8.74% of those women without PCOS (25).

A 2021 study published in Reproductive Biology and Endocrinology has found that hyperuricemia can increase the risk of female reproductive disorders, including PCOS and endometriosis (26). They found that high uric acid may also lead to pregnancy complications.

Testing Uric Acid Levels

Checking your uric acid levels is critical, especially if you are dealing with symptoms of the above-mentioned health issues linked to high uric acid. The normal clinical range for uric acid that most doctors recommend is between 2.6 and 7.6 mg/dL. The functional range that us, functional medicine doctors, prefer is between 3.0 5.5 mg/dL. 

High uric acid is not good but you don’t want it to get too low either. Low uric acid levels can also be a problem. Under 3 mg/dL may be a sign of poor phase II liver sulfation processes. The goal of Phase 2 of liver detoxification is conjugation. This is when your body removes metabolites from Phase I through bile, urine, and stool to reduce oxidative stress.

The conjugation process involves 6 major metabolic pathways including methylation, sulfation, glucuronidation, glutathione conjugation, acetylation, and glycation. Low uric acid may be a sign of issues with sulfation and a potential molybdenum deficiency. You can learn more about liver function and Phase II liver sulfation in this article.

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Comprehensive Blood Analysis 

To look at your uric acid levels and kidney functions, and other important health markers I recommend using the Comprehensive Blood Analysis (CBA). It is a very detailed blood test that looks at all of these markers of inflammation and other health functions.

This test is more sophisticated than most conventional doctors run. It looks at everything that a CBC and CMP do and more. It examines all parameters for inflammation, blood sugar levels, insulin levels, immune system function, thyroid function, parathyroid hormone levels, mineral and electrolyte balance, zinc and copper ratio, vitamin A and D levels, folate and vitamin B12 levels, a complete metabolic panel, complete blood count, liver function, kidney function, urinary tract health, nutrient deficiencies, and more. 

I recommend getting the Comprehensive Blood Analysis done regularly both as a preventative measure and to monitor your inflammation levels and progress if you are on a treatment plan. Remember, our team is always happy to help to understand your results and create a personalized treatment protocol to regain your health and well-being naturally.

, Comprehensive Blood Analysis

Genetic Polymorphisms Associated with High Uric Acid

Genetic polymorphism refers to certain mutations in the genotype. It describes a simultaneous incidence of two or more discontinuous genotypes or alleles. Genetic polymorphism may also be associated with hyperuricemia. According to a 2007 study published in PLoS Genetics, the GLUT9 gene may be associated with high uric acid (27).

According to a 2018 study published in Scientific Reports, the ABCG2 gene may also be linked to high uric acid and gout (28). According to a 2008 study published in National Genetics, the ALC2A9 gene is also associated with high uric acid levels (29). Along with complete blood testing, you may also benefit from some genetic testing.

How to Reduce Uric Acid Levels

As you now understand, high uric acid levels have been linked to a long list of health issues. The good news is that you can reduce your uric acid levels with the help of some natural support strategies.

If you want to learn more about this topic and how to reduce uric acid levels I highly recommend reading  Drop Acid: The Surprising New Science of Uric Acid. If you want to reduce your uric acid levels and improve your health, here are the natural support strategies I recommend:

Reduce Alcohol, Sugar, and Fructose Intake

Drinking too much alcohol and consuming food and drinks with too much sugar and fructose may increase the risk of high uric acid and related health issues (1, 2, 3). A 2010 review published in the JAMA has found that drinking beverages high in fructose may increase the risk of gout in females (30). A 2008 review published in BMJ has found that high fructose intake may increase the risk of high uric acid in men as well (31)

A 2013 review published in Diabetes has linked both fructose and table sugar to an increased risk of hyperuricemia, increased visceral fat, and diabetes (32). A 2014 study published in the American Journal of Medicine has found that too much alcohol may increase the risk of high uric acid and gout (33).

Lowering your intake of sugar, fructose, and alcohol may also reduce the risk of obesity, diabetes, and other health issues that are connected to high uric acid. I recommend reducing your alcohol intake to occasional moderate intake or removing alcohol completely. I also recommend reducing your intake of refined sugar and fructose which should only come from low-glycemic index fruits and vegetables.

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Consider Lowering Purines

Eating foods high in purine may lead to high uric acid levels and recurrent gout attacks (4, 5). A 2012 study published in Nutrition, Metabolism, and Cardiovascular Disease has found that foods high in protein may increase the risk of hyperuricemia (34). A 2019 review published in Nutrients has found that a low-purine diet may help to reduce uric acid levels, gout, and cardiovascular risk factors (35).

If you struggle with high uric acid levels, I recommend lowering your intake of foods higher in purines such as salmon, shrimp, sardines, lobsters, mackerel, anchovies and some other seafood, red meat, liver and other organ meats, dried beans, peas, alcohol, and food and drinks made with high fructose corn syrup.

Instead, switch to a low-purine whole foods diet rich in greens, vegetables, sprouts, herbs, spices, fermented foods, healthy fats, such as avocados, coconut oil, pasture-raised butter and ghee, olives, and extra virgin olive oil, and low-purine protein sources, such as grass-fed eggs and poultry, cold-water fish, such as tuna, and nuts and seeds.

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Practice Intermittent Fasting

Intermittent fasting is a type of eating. It cycles between a period of fasting and a period of eating within one day. The most common form of intermittent fasting includes 16 hours of fasting, including your overnight sleep and 8 hours reserved for your meals to meet your nutritional needs. Intermittent fasting may improve autophagy, insulin sensitivity, digestion, inflammation, and other factors of health. Intermittent fasting may also help to reduce uric acid levels.

A 2019 review published in Nutrients has found that fasting and calorie restriction along with a low-purine diet may help to reduce uric acid levels, gout, and cardiovascular risk factors (35). At first, uric acid levels will rise during fasting, but post-fasting, it will return to normal levels. A 2019 case study published in Cureus has found that uric acid levels reduced and returned to normal after the fasting period of short-term intermittent fasting (36).

A 2021 study published in Clinical Diabetes and Endocrinology has found that intermittent fasting may also improve insulin resistance and diabetes (37). This is important because insulin resistance and diabetes may contribute to high uric acid levels and this may increase the risk of insulin resistance and diabetes. (9, 10).

If you are new to intermittent fasting, begin with a 12-hour fast including your overnight sleep starting after dinner until the next day at breakfast. Gradually increase your fasting window by delaying breakfast and/or choosing an earlier dinner.

Most people feel the best with the 16:8 approach but you may find that fasting for a bit less or longer than 16 hours works better for you. To learn more about the benefits of intermittent fasting and the best intermittent fasting strategies, I recommend this article.

Regular Exercise

Regular movement and exercise may also help to reduce your uric acid levels. According to a 2015 study published in the Annals of the Rheumatic Diseases, an inactive lifestyle may be linked to high uric acid levels, however, being active helped to decrease uric acid levels and mortality (38). A 2021 study published in Frontiers in Endocrinology (Lausanne) has found that moderate exercise offers the optimal benefits for reducing uric acid levels compared to low-level exercise or no exercise at all (39)

A 2015 study published in the American Journal of Lifestyle Medicine has found that the combination of exercise, limiting calorie intake, and weight loss may contribute to improved uric acid levels (40). However, they found that strenuous exercise and over exercising and undereating causing ‘starvation’ can actually increase uric acid and trigger gout. 

Instead of over-exercising and under-eating, aim for long-term sustainable changes with regular moderate exercise and daily movement combined with a healthy diet and other healthy lifestyle choices. I recommend moving your body daily by getting up from your desk to stretch, taking a stroll in the park, biking or walking instead of driving, or playing with your pets and kids. 

I recommend at least 20 to 30 minutes of moderate exercise five times a week combining strength-, resistance-, and cardiovascular exercise. Hiking, biking, swimming, and rebounding are great ways to get some cardio in. Weight lifting with free weights and weight machines, resistance band exercises, kettlebell workouts, and bodyweight exercises are great for resistance and strength training. Pilates and yoga are low-impact ways to build some strength and tone your body. 

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Good Hydration

Healthy kidney function is critical for removing excess uric acid from your body (18, 19). Good hydration can support kidney function and may improve uric acid levels. According to a 2015 review published in the American Journal of Lifestyle Medicine, exercise-related heavy sweating may increase uric acid and rehydration is critical to reducing uric acid levels (41).

A 2016 study published in BMJ Open has found that heart stress may decrease kidney function and increase uric acid levels making hydration important for reducing uric acid and improving kidney function (42). A 2017 meeting abstract from the American College of Rheumatology Annual Meeting has also found that good hydration may help to reduce uric acid and the risk of gout (43).

I recommend starting your day with a 16 to 32 oz. glass of water. Drink water throughout the day, about 8 oz. every hour. If you don’t enjoy the taste of water, you may add some lemon juice or add some cucumber or other veggie slices for flavor. I also recommend trying hydrogen water, you can learn about its benefits here. Eating hydrating vegetables, such as cucumber, celery, and romaine lettuce, eating soup, and drinking bone broth, herbal tea, green juices, green smoothies, or protein shakes can add extra hydration.

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Optimize Vitamin D Levels 

Vitamin D is an essential vitamin for your bone, muscle, immune, brain, and overall health. Improving your vitamin D may help to reduce uric acid levels. A 2020 study published in Frontiers in Nutrition has found a link between vitamin D levels and hyperuricemia (44).

Researchers found that low vitamin D levels may be associated with high uric acid and vitamin D supplementation may help to improve uric acid levels. A 2021 study published in the Journal of Clinical & Translational Endocrinology has found that vitamin D supplementation may be beneficial for people with hyperuricemia and prediabetes (45).

To improve your vitamin D levels, I recommend spending time out in the sun as often as possible and eating egg yolks from pasture-raised chickens.  Most people are not getting enough sunshine or consuming enough vitamin D from food. Therefore, most people need supplements to optimize their vitamin D levels. 

Pairing vitamin D3 with vitamin K2 helps improve calcium absorption and inflammation control. I recommend taking a vitamin D3 supplement with at least 3,000-5,000 IU’s of vitamin D3 and at least 90 mcg of vitamin K2

Typically, taking 1,000 IU per 25 lbs. of body weight will help you get your levels into a healthy range. You want to test your vitamin D levels at least 1-2 times each year and get your levels between 50-100 ng/ml. It has been hypothesized that a therapeutic level for major health conditions is going to be between 70-100 ng/ml.

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Optimize Zinc Levels 

Zinc is a critical mineral for your immune and overall health. Zinc deficiency may increase your risk of high uric acid. A 2018 study published in Nutrients has found that low zinc intake is common in adults in the US and low zinc levels may be associated with high uric acid (46). Supplementation may help.

A 2020 study published in the International Journal of Fertility and Sterility has found that zinc supplementation may help to restore healthy uric acid levels (47)I recommend eating plenty of foods that are rich in zinc, such as meat, poultry, shellfish, eggs, dairy, seeds, nuts, legumes, sweet potatoes, quinoa, and green leafy vegetables.  Obviously some of these foods are higher in purines so you may also consider using zinc supplementation to balance your zinc levels.  

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Vitamin C  

We all know about vitamin C as an important vitamin for your immune system. No wonder most people reach for oranges and vitamin C supplements when feeling sick. Vitamin C may also help with uric acid levels too. A 2009 study published in the Archives of Internal Medicine has found that higher vitamin C intake may be linked to lower uric acid levels (48)

Vitamin C supplementation may help to improve your levels. A 2011 meta-analysis of randomized controlled trials published in Arthritis Care & Research (Hoboken) has found that vitamin C supplementation may help to improve serum uric acid levels (49). I recommend eating foods rich in vitamin C, such as lemon, lime, broccoli, and Brussels sprouts. You may also benefit from taking a high quality vitamin C supplement.

Quercetin 

Quercetin is an antioxidant and flavanol found in many plant foods, including black currants, cherries, blueberries, black plums, cranberries, apples, grapes, sage, broccoli, olive oil, pepper, kale, romaine lettuce, red leaf lettuce, raw red onions, snap peas, cabbage, raw asparagus, sprouts, and herbs.

Quercetin has many great benefits including reduced inflammation and lower histamine levels. It may also help with reducing your uric acid levels.

A 2016 randomized, double-blinded, placebo-controlled, cross-over clinical trial published in the British Journal of Nutrition has found that quercetin may help to lower uric acid levels (50). A 2021 study published in Free Radical Biology & Medicine has found that quercetin may help uric acid biosynthesis and may help to reduce uric acid levels (51). Taking 500-1000 mg of quercetin daily can be a great supplement to take to help regulate inflammation in the body.  

Resveratrol 

Resveratrol is a powerful antioxidant found in the skin of grapes, berries, and red wine. It greatly compliments the benefits of quercetin. It is known for its benefits for reducing inflammation, which may bring all kinds of other benefits to your body, including lower uric acid levels.

A 2016 study published in Clinical Rheumatology has found that resveratrol may help to reduce uric acid and gout attacks (52). A 2021 study published in Molecular Medicine Reports has found that resveratrol may help to reduce inflammation which may help to reduce uric acid levels (53)

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Green Tea 

Green tea is one of the healthiest teas out there. It is full of antioxidants and potential health benefits, including fat burning, weight loss, improved cognition, better blood sugar balance, and longevity. Green tea may also help to lower uric acid levels.

A 2015 animal study published in the Journal of Ethnopharmacology has found that green tea polyphenols may help to reduce uric acid levels (54). A 2021 randomized controlled trial published in Clinical Rheumatology has found that green tea catechins may help to reduce uric acid and gout (55). I recommend drinking green tea or taking green tea extract supplements to improve your health.

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Tart Cherry 

Tart cherries are also known as sour cherries, Montmorency, or dwarf cherries. They are full of nutrients and have many health benefits, including muscle health, improved sleep, improved immune health, and less joint pain. They may also help with reducing your uric acid levels.

A 2020 animal study published in Evidence-based Complementary and Alternative Medicine has found that tart cherry powder may help to reduce uric acid levels in hyperuricemia (56). A 2020 randomized controlled trial published in BMJ Open has found that tart cherry juice may help to reduce gout attacks (57). You may benefit from drinking tart cherry juice if you have high uric acid levels or gout.

Gout, Gout: Symptoms, Causes and Natural Support Strategies

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Final Thoughts

Uric acid is a natural waste product in your blood that helps to break down purines. Normally this acid is dissolved and moves through your kidneys and gets removed through urine.

However, if your body cannot remove all excess uric acid, it can lead to a build-up causing hyperuricemia, which may lead to kidney stones, gout, and other health issues. Fortunately, you can reduce your uric acid levels naturally. I recommend following my natural support strategies to reduce levels and to improve your health and well-being.

If you want to work with a functional health coach, I recommend this article with tips on how to find a great coach. On our website, we offer long-distance functional health coaching programs. For further support with your health goals, just reach out—our fantastic coaches are here to support your journey.

Inflammation Crushing Ebundle

The Inflammation Crushing Ebundle is designed to help you improve your brain, liver, immune system and discover the healing strategies, foods and recipes to burn fat, reduce inflammation and Thrive in Life!

As a doctor of natural medicine, I have spent the past 20 years studying the best healing strategies and worked with hundreds of coaching clients, helping them overcome chronic health conditions and optimize their overall health.

In our Inflammation Crushing Ebundle, I have put together my very best strategies to reduce inflammation and optimize your healing potential.  Take a look at what you will get inside these valuable guides below!

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Sources in This Article Include:

1. Rho YH, Zhu Y, Choi HK. The epidemiology of uric_acid and fructose. Semin Nephrol. 2011 Sep;31(5):410-9. doi: 10.1016/j.semnephrol.2011.08.004. PMID: 22000647
2. Caliceti C, Calabria D, Roda A, Cicero AFG. Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A Critical Review. Nutrients. 2017 Apr 18;9(4):395. doi: 10.3390/nu9040395. PMID: 28420204
3. Congwang Zhang, Lijun Li, Yipeng Zhang, Changchun Zeng, Recent advances in fructose intake and risk of hyperuricemia, Biomedicine & Pharmacotherapy, Volume 131, 2020, Link Here
4. Zhang Y, Chen C, Choi H, Chaisson C, Hunter D, Niu J, Neogi T. Purine-rich foods intake and recurrent gout attacks. Ann Rheum Dis. 2012 Sep;71(9):1448-53. doi: 10.1136/annrheumdis-2011-201215. Epub 2012 May 30. PMID: 22648933
5. Zgaga L, Theodoratou E, Kyle J, Farrington SM, Agakov F, Tenesa A, Walker M, McNeill G, Wright AF, Rudan I, Dunlop MG, Campbell H. The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study. PLoS One. 2012;7(6):e38123. doi: 10.1371/journal.pone.0038123. Epub 2012 Jun 6. PMID: 22701608
6. Gout. CDC. Link Here
7. Ruoff G, Edwards NL. Overview of Serum Uric_Acid Treatment Targets in Gout: Why Less Than 6 mg/dL? Postgrad Med. 2016 Sep;128(7):706-15. doi: 10.1080/00325481.2016.1221732. Epub 2016 Aug 25. PMID: 27558643
8. Ragab G, Elshahaly M, Bardin T. Gout: An old disease in new perspective – A review. J Adv Res. 2017 Sep;8(5):495-511. doi: 10.1016/j.jare.2017.04.008. Epub 2017 May 10. PMID: 28748116
9. Rho YH, Lu N, Peloquin CE, Man A, Zhu Y, Zhang Y, Choi HK. Independent impact of gout on the risk of diabetes mellitus among women and men: a population-based, BMI-matched cohort study. Ann Rheum Dis. 2016 Jan;75(1):91-5. doi: 10.1136/annrheumdis-2014-205827. Epub 2014 Oct 2. PMID: 25277955
10. Annals of internal medicine 2020 Link Here
11. Oral A, Sahin T, Turker F, Kocak E. Relationship Between Serum Uric_Acid Levels and Nonalcoholic Fatty Liver Disease in Non-Obese Patients. Medicina (Kaunas). 2019 Sep 17;55(9):600. doi: 10.3390/medicina55090600. PMID: 31533345
12. Zheng X, Gong L, Luo R, Chen H, Peng B, Ren W, Wang Y. Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults. Lipids Health Dis. 2017 Oct 16;16(1):202. doi: 10.1186/s12944-017-0531-5. PMID: 29037239
13. Mazzali M, Kanbay M, Segal MS, Shafiu M, Jalal D, Feig DI, Johnson RJ. Uric_acid and hypertension: cause or effect? Curr Rheumatol Rep. 2010 Apr;12(2):108-17. doi: 10.1007/s11926-010-0094-1. PMID: 20425019
14. Johnson RJ. 2003.  Hypertension Link Here
15. Lanaspa, M.A., Andres-Hernando, A. & Kuwabara, M. Uric acid and hypertension. Hypertens Res 43, 832–834 (2020). LInk Here
16. Tana C, Ticinesi A, Prati B, Nouvenne A, Meschi T. Uric Acid and Cognitive Function in Older Individuals. Nutrients. 2018 Jul 27;10(8):975. doi: 10.3390/nu10080975. PMID: 30060474
17. Kim Jee Wook, Byun Min Soo, Yi Dahyun, Lee Jun Ho, Jeon So Yeon, Ko Kang, Jung Gijung, Lee Han Na, Lee Jun-Young, Sohn Chul-Ho, Lee Yun-Sang, Shin Seong A, Kim Yu Kyeong, Lee Dong Young,  for the KBASE Research Group. Serum Uric Acid, Alzheimer-Related Brain Changes, and Cognitive Impairment. Frontiers in Aging Neuroscience. 2020. Link Here
18. Kang DH, Chen W. Uric acid and chronic kidney disease: new understanding of an old problem. Semin Nephrol. 2011 Sep;31(5):447-52. doi: 10.1016/j.semnephrol.2011.08.009. PMID: 22000652
19. 2015 Disease Markers. Link Here
20. Duke University Medical Center. “Uric_acid may increase likelihood of severe osteoarthritis.” ScienceDaily. ScienceDaily, 18 January 2011. Link Here
21. Ma CA, Leung YY. Exploring the Link between Uric_Acid and Osteoarthritis. Front Med (Lausanne). 2017 Dec 13;4:225. doi: 10.3389/fmed.2017.00225. PMID: 29326934
23. Yan, Dd., Wang, J., Hou, Xh. et al. Association of serum uric_acid levels with osteoporosis and bone turnover markers in a Chinese population. Acta Pharmacol Sin 39, 626–632 (2018). Link Here
24. Lin KM, Lu CL, Hung KC, Wu PC, Pan CF, Wu CJ, Syu RS, Chen JS, Hsiao PJ, Lu KC. The Paradoxical Role of Uric Acid in Osteoporosis. Nutrients. 2019 Sep 5;11(9):2111. doi: 10.3390/nu11092111. PMID: 31491937
25. Mu L, Pan J, Yang L, Chen Q, Chen Y, Teng Y, Wang P, Tang R, Huang X, Chen X, Yang H. Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome. Reprod Biol Endocrinol. 2018 Oct 25;16(1):104. doi: 10.1186/s12958-018-0419-x. PMID: 30359269
26. Hu, J., Xu, W., Yang, H. et al. Uric_acid participating in female reproductive disorders: a review. Reprod Biol Endocrinol 19, 65 (2021). Link Here
27. 2007 PLOS Genetics Link Here
28. Chen, CJ., Tseng, CC., Yen, JH. et al. ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study. Sci Rep 8, 3137 (2018). Link Here
29. Vitart V, Rudan I, Hayward C, Gray NK, Floyd J, Palmer CN, Knott SA, Kolcic I, Polasek O, Graessler J, Wilson JF, Marinaki A, Riches PL, Shu X, Janicijevic B, Smolej-Narancic N, Gorgoni B, Morgan J, Campbell S, Biloglav Z, Barac-Lauc L, Pericic M, Klaric IM, Zgaga L, Skaric-Juric T, Wild SH, Richardson WA, Hohenstein P, Kimber CH, Tenesa A, Donnelly LA, Fairbanks LD, Aringer M, McKeigue PM, Ralston SH, Morris AD, Rudan P, Hastie ND, Campbell H, Wright AF. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet. 2008 Apr;40(4):437-42. doi: 10.1038/ng.106. Epub 2008 Mar 9. PMID: 18327257
30. Choi HK, Willett W, Curhan G. Fructose-rich beverages and risk of gout in women. JAMA. 2010 Nov 24;304(20):2270-8. doi: 10.1001/jama.2010.1638. Epub 2010 Nov 10. PMID: 21068145
31. 2008 BMJ. Link Here
32. Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, Ishimoto T, Sautin YY, Lanaspa MA. Sugar, uric_acid, and the etiology of diabetes and obesity. Diabetes. 2013 Oct;62(10):3307-15. doi: 10.2337/db12-1814. PMID: 24065788
33. Neogi T, Chen C, Niu J, Chaisson C, Hunter DJ, Zhang Y. Alcohol quantity and type on risk of recurrent gout attacks: an internet-based case-crossover study. Am J Med. 2014 Apr;127(4):311-8. doi: 10.1016/j.amjmed.2013.12.019. Epub 2014 Jan 17. PMID: 24440541
34. Villegas R, Xiang YB, Elasy T, Xu WH, Cai H, Cai Q, Linton MF, Fazio S, Zheng W, Shu XO. Purine-rich foods, protein intake, and the prevalence of hyperuricemia: the Shanghai Men’s Health Study. Nutr Metab Cardiovasc Dis. 2012 May;22(5):409-16. doi: 10.1016/j.numecd.2010.07.012. Epub 2011 Jan 28. PMID: 21277179
35. Vedder D, Walrabenstein W, Heslinga M, de Vries R, Nurmohamed M, van Schaardenburg D, Gerritsen M. Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review. Nutrients. 2019 Dec 4;11(12):2955. doi: 10.3390/nu11122955. PMID: 31817107
36. Ooi SL, Pak SC. Short-term Intermittent Fasting for Weight Loss: A Case Report. Cureus. 2019 Apr 16;11(4):e4482. doi: 10.7759/cureus.4482. PMID: 31249759
37. Albosta, M., Bakke, J. Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians. Clin Diabetes Endocrinol 7, 3 (2021). Link Here
38. Chen J, Wen CP, Wu SB, et alAttenuating the mortality risk of high serum uric_acid: the role of physical activity underusedAnnals of the Rheumatic Diseases 2015;74:2034-2042. Link Here
39. Hou Y, Ma R, Gao S, Kaudimba KK, Yan H, Liu T, Wang R. The Effect of Low and Moderate Exercise on Hyperuricemia: Protocol for a Randomized Controlled Study. Front Endocrinol (Lausanne). 2021 Sep 2;12:716802. doi: 10.3389/fendo.2021.716802. PMID: 34539569
40. Kakutani-Hatayama M, Kadoya M, Okazaki H, Kurajoh M, Shoji T, Koyama H, Tsutsumi Z, Moriwaki Y, Namba M, Yamamoto T. Nonpharmacological Management of Gout and Hyperuricemia: Hints for Better Lifestyle. Am J Lifestyle Med. 2015 Sep 2;11(4):321-329. doi: 10.1177/1559827615601973. PMID: 30202351
41. Kakutani-Hatayama M, Kadoya M, Okazaki H, Kurajoh M, Shoji T, Koyama H, Tsutsumi Z, Moriwaki Y, Namba M, Yamamoto T. Nonpharmacological Management of Gout and Hyperuricemia: Hints for Better Lifestyle. Am J Lifestyle Med. 2015 Sep 2;11(4):321-329. doi: 10.1177/1559827615601973. PMID: 30202351
42. Wesseling C, Aragón A, González M, Weiss I, Glaser J, Rivard CJ, Roncal-Jiménez C, Correa-Rotter R, Johnson RJ. Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua. BMJ Open. 2016 Dec 8;6(12):e011034. doi: 10.1136/bmjopen-2016-011034. Erratum in: BMJ Open. 2017 Jan 25;7(1):e011034corr1. PMID: 27932336
43. Hydration and Gout. 2017. American College of Rheumatology Annual Meeting Link Here
44. Zhang Yi-Ying, Qiu Hong-Bin, Tian Jin-Wei. Association Between Vitamin D and Hyperuricemia Among Adults in the United States. Frontiers in Nutrition 2020 Link Here
45. Hataikarn Nimitphong, Sunee Saetung, La-or Chailurkit, Suwannee Chanprasertyothin, Boonsong Ongphiphadhanakul, Vitamin D supplementation is associated with serum uric acid concentration in patients with prediabetes and hyperuricemia, Journal of Clinical & Translational Endocrinology. 2021 Link Here
46. Zhang Y, Liu Y, Qiu H. Association between Dietary Zinc Intake and Hyperuricemia among Adults in the United States. Nutrients. 2018 May 5;10(5):568. doi: 10.3390/nu10050568. PMID: 29734733
47. Alsalman ARS, Almashhedy LA, Alta’ee AH, Hadwan MH. Effect of Zinc Supplementation on Urate Pathway Enzymes in Spermatozoa and Seminal Plasma of Iraqi Asthenozoospermic Patients: A Randomized Controlled Trial. Int J Fertil Steril. 2020 Jan;13(4):315-323. doi: 10.22074/ijfs.2020.5760. Epub 2019 Nov 11. PMID: 31710193
48. Choi HK, Gao X, Curhan G. Vitamin C intake and the risk of gout in men: a prospective study. Arch Intern Med. 2009 Mar 9;169(5):502-7. doi: 10.1001/archinternmed.2008.606. PMID: 19273781
49. Juraschek SP, Miller ER 3rd, Gelber AC. Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controlled trials. Arthritis Care Res (Hoboken). 2011 Sep;63(9):1295-306. doi: 10.1002/acr.20519. PMID: 21671418
50. Shi Y. Quercetin lowers plasma uric acid. 2016 British journal of nutrition. Link Here
51. Tumova S, Shi Y, Carr IM, Williamson G. Effects of quercetin and metabolites on uric acid biosynthesis and consequences for gene expression in the endothelium. Free Radic Biol Med. 2021 Jan;162:191-201. doi: 10.1016/j.freeradbiomed.2020.10.017. Epub 2020 Oct 19. PMID: 33091574
52. Chen H, Zheng S, Wang Y, Zhu H, Liu Q, Xue Y, Qiu J, Zou H, Zhu X. The effect of resveratrol on the recurrent attacks of gouty arthritis. Clin Rheumatol. 2016 May;35(5):1189-95. doi: 10.1007/s10067-014-2836-3. Epub 2014 Dec 3. PMID: 25451618
53. Zhang X. Resveratrol affects expression of uric_acid. Molecular Medicine Reports. 2021 Link Here
54. Chen G, Tan ML, Li KK, Leung PC, Ko CH. Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice. J Ethnopharmacol. 2015 Dec 4;175:14-20. doi: 10.1016/j.jep.2015.08.043. Epub 2015 Sep 3. PMID: 26344851
55. Kawakami Y, Yasuda A, Hayashi M, Akiyama M, Asai T, Hosaka T, Arai H. Acute effect of green tea catechins on uric_acid metabolism after alcohol ingestion in Japanese men. Clin Rheumatol. 2021 Jul;40(7):2881-2888. doi: 10.1007/s10067-021-05625-7. Epub 2021 Feb 10. PMID: 33569708
56. Li R, Tan Y, Li Y, Zhu X, Tang X, Zhang L, Chen J. Effects of Tart Cherry Powder on Serum Uric_Acid in Hyperuricemia Rat Model. Evid Based Complement Alternat Med. 2020 Jul 22;2020:1454305. doi: 10.1155/2020/1454305. PMID: 32774405
57. Lamb KL, Lynn A, Russell J, Barker ME. Effect of tart cherry juice on risk of gout attacks: protocol for a randomised controlled trial. BMJ Open. 2020 Mar 15;10(3):e035108. doi: 10.1136/bmjopen-2019-035108. PMID: 32179562

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  1. I understand I have a long history of to much acids. Not only in the blood but also accumulated in my organs. I´ve prostatecancer, kidney failure, psoriasis, sometimes gout, sleeping issues and much more.
    So I´ve found out I´ve an reaction to acids in general. Wether it be salicylates, oxalates, benzoates, they all worsen my condition. Inflammation in my body raises when they are ingested. I can´t even supplement with vitamin C.
    That´s why recommended diets don´t apply for me. I need to have a diet as acid-free as possible. And if that´s a problem for me I guess it could be a problem for others too.

  2. I was about to purchase the Drop Acid book you mentioned above, but upon reading the reviews, many readers were disappointed about the authors ‘push’ of evolution and rambling on with not good information behind what he says. Was really wanting to dive into a deeper study of uric acid but I’m not sure that this particular author is for me.

  3. This is great, however after reading the new book out called “Toxic Superfoods” by Sally K Norton about oxalate overload, these 2 health “problems” seem to overlap…yet with oxalate sensitivity you definitely don’t want to take high doses ( over 250mg) of vitamin C for example and should avoid green tea which is full of oxylates. ( most teas are, except for herbal tea) How would one know which problem they had?

  4. I had all of these issues and the only thing that worked for ALL of my auto immune issues was taking out ALL plants nuts seeds- I eat animal based with plenty of saturated fats and have my best body back! Encouraging sick ppl to eat plants and nuts is so misguided! Took me 50 years to figure this out to reverse my thinking on what is “healthy” and human healthful.

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